Table 1.
Sentinel variants in eight regions significantly associated with moderate-to-severe asthma risk in this GWAS of 3181 cases and 3590 controls (OR = odds ratio for coded allele, SE = standard error, PDE = p-value for the differential effects test, RAF = risk allele frequency for AMD and RA controls, respectively).
| SNP | CHR | BP (GRCh38) | Nearest gene | Risk/non-risk allele | OR | SE | P-value | PDE | RAFcase | RAFcontrol |
|---|---|---|---|---|---|---|---|---|---|---|
| rs139210940 | 2 | 102,265,885 | IL1RL2 | AT/A | 1.339 | 0.051 | 8.08 × 10–9 | 0.333 | 0.879 | 0.847, 0.843 |
| rs10455025 | 5 | 111,069,301 | TSLP | C/A | 1.304 | 0.037 | 4.36 × 10–13 | 0.856 | 0.387 | 0.34, 0.326 |
| rs17205170 | 6 | 32,634,706 | HLA-DQA1 | G/T | 1.449 | 0.046 | 7.92 × 10–16 | 0.168 | 0.84 | 0.797, 0.779 |
| rs2875584 | 6 | 90,240,909 | BACH2 | C/T | 1.238 | 0.038 | 1.57 × 10–8 | 0.351 | 0.706 | 0.666, 0.653 |
| rs7130588 | 11 | 76,559,639 | C11orf30 | G/A | 1.242 | 0.036 | 2.46 × 10–9 | 0.04 | 0.386 | 0.358, 0.332 |
| rs2104047 | 14 | 68,287,700 | RAD51B | T/C | 1.245 | 0.039 | 1.28 × 10–8 | 0.134 | 0.312 | 0.262, 0.274 |
| rs11631778 | 15 | 71,314,041 | THSD4 | G/A | 1.225 | 0.037 | 3.54 × 10–8 | 0.436 | 0.354 | 0.305, 0.311 |
| rs7216558 | 17 | 39,913,818 | GSDMB | T/C | 1.263 | 0.035 | 1.91 × 10–11 | 0.442 | 0.545 | 0.479, 0.494 |