Table 4.
Anti-oxidant effects of the constituents of Ferula species
| Constituents | Doses | Model of study | Effects | Ref. |
|---|---|---|---|---|
| Kamolonol acetate | 2.5, 5, 10, 20, 40, and 80 μM | DPPH radical scavenging assay | Radical scavenging activity | (59) |
| Umbelliprenin | 0.01 mmol/kg | Carrageenan-induced rat paw edema | Inhibited lipoxygenase activity | (33) |
| Kamolonol acetate | 2.5, 5, 10, 20, 40, and 80 μM | HCT116, CT26, Vero and MSCs, DPPH antioxidant | Reduced radical scavenging activity | (58) |
| Auraptene | 5, 10, 25, 50, 100, 200, and 400 mM | DNA damage in human T-cells | Antigenotoxic effects on DNA damage, reduced H2O2 genotoxicity | (66) |
| Auraptene | 12.5, 25, and 50 mg/kg | Brain tissue of Kindling mice | Increased GSH levels | (67) |
| Auraptene | 4, 8, and 25 mg/kg, orally | Vascular dementia and chronic cerebral hypoperfusion models | Decreased MDA but increased GSH | (68) |
| Umbelliprenin | 10, 25, 50, 100, 200, and 400 μM | Human lymphocytes DNA lesions | Reduced DNA damage | (53) |
GSH: glutathione, MDA: malondialdehyde, ROS: reactive oxygen species, MCF-7: Michigan Cancer Foundation-7, DPPH: 2,2-diphenyl-1-picrylhydrazyl, HCT116: human colon cancer cell line, H2O2: Hydrogen peroxide, DPPH: 2,2-diphenyl-1-picrylhydrazyl, MSCs: Mesenchymal stem cells, CT26: Animal fibroblast cells