Figure 6.

Alpha biodiversity indices after treatment with methotrexate (MTX) and mycophenolate mofetil (MMF) in immunized (experimental autoimmune uveitis) and non-immunized controls. Firmicutes/Bacteroidetes ratio (A), observed taxonomic units (B), Shannon index (C), and Simpson index (D). H₂O, water-fed. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data expressed as mean ± standard deviation; n = 7 to 8 mice per group (non-immunized), and 8 to 20 mice per group (immunized). Time-point = 6 weeks post-treatment initiation, 2 weeks post-immunization.