Figure 8.

Partial least-squares discriminant analysis (PLS-DA) in immunized (experimental autoimmune uveitis) mice. Results between water-fed and methotrexate-treated (A), and between water-fed and mycophenolate mofetil-treated (B) animals. Only the 10 covariates with highest standardized scores (SC) plus reference control are shown, all P < 0.05. MTX, methotrexate; MMF, mycophenolate mofetil; H₂O, water-fed controls; w, weeks; Y, eye; L, gut lamina propria; M, mesenteric lymph node; Abs., absolute CD₄⁺ lymphocyte counts. Time-point = 6 weeks post-treatment initiation, 2 weeks post-immunization.