Figure 1.

Mitochondrial protein acetylation and GCN5L1 are upregulated in female mice. A: immunoblotting of mitochondrial lysate fractions from male and female mice demonstrate that females exhibit modestly but significantly higher levels of total protein acetylation. n = 10. B: GCN5L1, but not SIRT3, mRNA is significantly increased in female hearts relative to males. C: GCN5L1 protein levels are significantly increased in the myocardium of female mice compared with male mice. n = 10, *P < 0.05, ***P < 0.001 vs. male (Student’s t test).