Figure 1.

Effect of pendrin gene ablation on urinary Na⁺, K⁺, and Cl⁻ excretion following dietary Na⁺, K⁺, and Cl⁻ restriction. Male pendrin-null and wild-type mice on a C57Bl/6 background were given 4 days of the NaCl-replete, K⁺-restricted diet (treatment 2), and then 8 days of the Na⁺, K⁺, and Cl⁻-restricted diet (treatment 1). Daily 24-h urinary volume as well as Na⁺, K⁺, and Cl⁻ excretion were measured in samples that were collected continuously over the last 9 days of the protocol (A). B: cumulative urinary volume and urinary Na⁺, K⁺, and Cl⁻ excretion over the 8 days of dietary Na⁺, K⁺, and Cl⁻ restriction. Solid black circles indicate individual data points for wild-type mice; solid gray circles are data points for pendrin-null mice. *P < 0.05 (Student’s t test).