Figure 2.

Epithelial Na⁺ channel inhibitors exacerbate the apparent intravascular volume contraction observed in pendrin-null mice. Blood urea nitrogen (BUN) was measured in male (A) and female (B) wild-type (WT) and pendrin-null [knockout (KO)] mice on a C57Bl/6 background following 7 days of the Na⁺, K⁺, and Cl⁻-restricted diet (treatment 1) or with diet and amiloride (treatment 4). Open circles represent the individual data points for mice in each group. *P < 0.05 (one-way ANOVA with a Holm–Sidak posttest).