Table 4.
Serum K+ and arterial blood gases in pendrin-null or wild-type pendrin mice harboring either wild-type ENaC or Liddle’s mutation given a NaCl-replete, K+-deficient diet (treatment 2)
| Strain | K+, meq |
|
|---|---|---|
| Male | Female | |
| Wild type(ENaCWTWT; Slc26a4+/+) | 3.9 ± 0.2 (n = 8) | 4.0 ± 0.1 (n = 3) |
| Pendrin null(ENaCWTWT; Slc26a4−/−) | 3.8 ± 0.4 (n = 4) | 3.8 ± 0.1 (n = 3) |
| Liddle’s(ENaCLL; Slc26a4+/+) | 3.5 ± 0.1 (n = 7) | 3.3 ± 0.2 (n = 4) |
| Liddle’s/pendrin null(ENaCLL; Slc26a4-/-) | 2.9 ± 0.2 (n = 6)* | 2.9 ± 0.1 (n = 5)† |
Data are means ± SE; n, number of mice studied. Mice were on a 129 SvEv Tac background. Sex-matched wild-type and pendrin-null littermates were compared with an unpaired t test. *P < 0.05; †P = 0.06.