Table 2.
Univariate and Multivariable Analysis associations with Progression Free Survival.
| Univariate Analysis |
Multivariable Analysis |
|||
|---|---|---|---|---|
| Covariate | Hazard Ratio (95% CI) |
HR P-value |
Hazard Ratio (95% CI) |
HR P-value |
| Age | 1.00 (0.96-1.06) | 0.898 | ||
| Sex, Male vs Female | 0.52 (0.09-2.16) | 0.424 | ||
| Karnofsky Performance Status | 0.99 (0.91-1.09) | 0.785 | ||
| Non-Secretory vs secretory | 1.22 (0.29-6.78) | 0.810 | ||
| Number of Surgeries | 1.20 (0.39-2.98) | 0.671 | ||
| Type of surgery: TSA vs craniotomy/other | 0.26 (0.05-2.50) | 0.165 | ||
| Knosp Grade: 0-1 vs 2-4 | 0.73 (0.16-3.04) | 0.680 | ||
| Extent of Surgery: GTR | 0.34 (0.00-65.18) | 0.631 | ||
| STR | 1.11 (0.12-148.15) | 0.952 | ||
| Biopsy or none | - | - | ||
| MIB-1: <3% vs ≥3% | 0.35 (0.03-2.65) | 0.382 | ||
| Pituitary Apoplexy (no vs yes) | 0.11 (0.02-1.12) | 0.030 | 0.12 (0.01-1.15) | 0.066 |
| SRS vs Fractionated radiotherapy | 0.63 (0.07-2.99) | 0.630 | ||
| EQD2 | 1.01 (0.85-1.07) | 0.837 | ||
| log PTV Volume | 2.41 (1.12-5.91) | 0.036 | 2.60 (1.08-6.28) | 0.033 |
Bolded for statistically significant (p<0.05)
TSA stands for transsphenoidal surgical approach. GTR stands for gross total resection and STR stands for subtotal resection. EQD2 is the equivalent dose for a radiation treatment if it were given in 2 Gy per fraction, used to normalize for different fractionation regimens