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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Biomaterials. 2022 Feb 23;283:121437. doi: 10.1016/j.biomaterials.2022.121437

Figure 3.

Figure 3.

In vivo biodistribution of SOD-NPs in DMM-injured mouse knee joint. (A) H&E staining of normal mouse knee joint showing the anatomy and location of synovium and cartilage. S: Synovium, C: Cartilage. (B) Representative fluorescence images of SOD(FITC)-NP(Rhod) distribution in mouse knee joints at day 0 (before injection) and 1, 3, 7 and 14 days after an intra-articular injection. Mice received DMM surgery two months before the injection. White boxes with the numbers in the joint images are magnified at the right to show synovium and cartilage. For synovial tissues, magnified regions labeled with FITC (green color), Rhod (red color) and the merged FITC, Rhod and DAPI (blue color) are provided, respectively. For cartilage tissues, only magnified regions from the merged FITC, Rhod and DAPI are provided. Scale bar: 200 μm. (C) Semi-quantification of rhodamine fluorescence intensity in synovium and cartilage. (n = 3 mice/group). (D) Immunofluorescence staining of Pdgfrα in mouse synovial tissue at 14 days post SOD(FITC)-NP(Rhod) injection. SSL: synovial sublining layer. Scale bar: 100 μm.