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. 2022 Mar 27;2022:1340194. doi: 10.1155/2022/1340194

Figure 4.

Figure 4

Codonopsis pilosula targeted HMOX1 via luteolin, capsaicin, and sulforaphane. (a) Codonopsis pilosula-component-target network showed that Codonopsis pilosula may target HMOX1 directly through apigenin, luteolin, capsaicin, sulforaphane, and geniposide. (b) Luteolin trends to upregulate Hmox1 in BV-2 cells (p=0.081). (c) Capsaicin could significantly upregulate Hmox1 in dorsal root ganglia neurons (p=0.029). (d) Apigenin could not affect the expression of HMOX1 in MCF-7 cells (p=0.901). (e) Sulforaphane could significantly enhance HMOX1 expression in MCF10A cells (p=0.0006). (f) Geniposide has no effect on the expression of HMOX1 in MCF-7 cells (p=0.56).