Figure 2.

The knockdown of circ_TNPO1 inhibited proliferation and migration progression of ox-LDL-induced VSMCs. (a) Relative expression levels of circ_TNPO1 were measured in VSMCs transfected with si-circ_TNPO1 or si-NC by RT-qPCR assay. (b) CCK-8 assay monitored proliferation activity of VSMCs after cotreatment with si-circ_TNPO1 or si-NC and ox-LDL. (c) Transwell assay monitored migration activity of VSMCs after cotreatment with si-circ_TNPO1 or si-NC and ox-LDL. (d) Western blot assay detected the protein expression levels of Ki67, PCNA, MMP2, E-cadherin, and N-cadherin in VSMCs after cotreatment with si-circ_TNPO1 or si-NC under ox-LDL stress. ^∗P < 0.05.