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. 2022 Mar 27;2022:4086935. doi: 10.1155/2022/4086935

Figure 4.

Figure 4

The blockage of miR-181b counteracted proliferation and migration suppressing effects of circ_TNPO1 knockdown in ox-LDL-induced VSMCs. (a) Relative expression levels of miR-181b were measured in VSMCs transfected with si-circ_TNPO1 alone, si-NC alone, or together with miR-181b inhibitor or miR-NC. (b) CCK-8 assay monitored proliferation activity of VSMCs transfected with si-circ_TNPO1 alone, si-NC alone, or together with miR-181b inhibitor or miR-NC under ox-LDL stress. (c) Transwell assay detected the migration activity of VSMCs transfected with si-circ_TNPO1 alone, si-NC alone, or together with miR-181b inhibitor or miR-NC under ox-LDL stress. (d) Western blot assay detected the protein expression levels of Ki67, PCNA, MMP2, E-cadherin, and N-cadherin in VSMCs transfected with si-circ_TNPO1 alone, si-NC, or together with miR-181b inhibitor or miR-NC under ox-LDL stress. P < 0.05.