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. 2022 Mar 27;2022:4086935. doi: 10.1155/2022/4086935

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Copyright © 2022 Mingxiang Chen et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Overexpression of Notch1 counteracted inhibition effects of proliferation and migration of circ_TNPO1 knockdown in ox-LDL-induced human VSMCs. (a) RT-qPCR assay determined Notch1 mRNA expression level in VSMCs transfected with si-NC, or si-circ_TNPO1, or si-circ_TNPO1 along with pcDNA plasmid or si-circ_TNPO1 along with pcDNA-Notch1 plasmid. (b) The effect of Notch1 overexpression on the proliferative activity of ox-LDL-induced VSMCs transfected with si-circ_TNPO1 was determined by the CCK-8 assay. (c) The effect of Notch1 overexpression on the migrating activity of ox-LDL-induced VSMCs transfected with si-circ_TNPO1 was determined by Transwell assay. (d) The effect of Notch1 overexpression on protein expression of Ki67, PCNA, MMP2, E-cadherin, and N-cadherin in ox-LDL-induced VSMCs transfected with si-circ_TNPO1 was determined by Western blot assay. ^∗P < 0.05.