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. 2022 Mar 30;15:2103–2119. doi: 10.2147/JIR.S350566

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© 2022 Zhang et al.

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NaB promotes survival of CLP mice and alleviates cognitive dysfunction of CLP surviving mice. Intragastric administration of NaB increased the butyrate level in blood and hippocampus of CLP mice. (A) Changes in the survival rate. There were 20 animals in Sham group, CLP group, and CLP+NaB treatment (NaB) group. (B) Butyric acid concentration in plasma of mice on the 1st day. (C) Butyric acid concentration in the hippocampus of mice on the 1st day. (D and E) The escape latency and swimming speed on the 1st, 2nd, 3rd, 4th, and 5th day of the learning trials. (F) The frequency of crossing the original platform location during the probe trial on the 6th day. (G) Representative swimming paths of mice during the probe trial on day 6 are depicted. (H) Representative H&E-stained sections of hippocampus of mice on the 1st day. Data presented as mean ± SD (n =3–7 per group). Scale bars: 100µm and 20µm. *P < 0.05 in A by Chi-square test. * P < 0.05, **P < 0.01, ***P < 0.001, **** P < 0.0001 in B, C, D, F by one-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001 in E by two-way ANOVA. ns: no significance.