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. 2022 Mar 30;15:2103–2119. doi: 10.2147/JIR.S350566

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© 2022 Zhang et al.

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Effect of NaB on GPR109A/Nrf2/HO-1 signaling in LPS-stimulated primary microglia. (A) Immunohistochemical stained sections showing expression of GPR109A in hippocampus. Arrows (→) indicate the cell nucleus. (B) Western blot analysis of GPR109A, Nrf2, HO-1, and NQO1 protein expressions in the primary microglia at 12h after LPS, LPS+NaB, and LPS+NaB+PTX and their corresponding controls. GAPDH served as the loading control. Bar graphs depicting the optical density of Nrf2, GPR109A, HO-1, and NQO1 expressions. Data presented as mean ± SD (n = 3 per group). Scale bars: 100µm and 20µm. *P < 0.05, **P < 0.01 by one-way ANOVA. ns: no significance.