Figure 1.

Potential $\mathrm{sNB}$ under recalibration. The dotted line shows 1 standard error below the estimated maximum possible $\mathrm{sNB}$ . In both (A) and (B), the estimated $\mathrm{sNB}$ for the original risk model is more than 1 standard error lower than the estimated maximum possible $\mathrm{sNB}$ , indicating that a recalibrated risk score could yield higher net benefit. In (A), the estimated $\mathrm{sNB}$ for the risk model after standard logistic recalibration is near the maximum value. Alternative methods of recalibration may not be worth pursuing in this setting. In (B), the recalibrated risk model produced by standard logistic recalibration yields estimated $\mathrm{sNB}$ more than 1 standard error lower than the estimated maximum possible $\mathrm{sNB}$ , suggesting that alternative recalibration methods may be useful.