TABLE 2.

RTR Immunosuppression Treatment on third vaccine Day Stratified by Antibody Response.

Immunosuppressive therapy	Total cohort (N = 99)	Negative (N = 14)	Positive (N = 85)	p value
Tacrolimus, n (%)	87 (87.9)	12 (85.7)	75 (88.2)	0.79
Tacrolimus daily dose (mg) on 3rd vaccine date [median (IQR)]	2 (1.5–3.0)	2.5 (1.5–3.0)	2 (2.0–3.0)	0.66
Tacrolimus daily dose (mg) per weight (kg) on 3rd vaccine day [median (IQR)]	0.03 (0.02–0.04)	0.03 (0.01–0.04)	0.03 (0.02–0.04)	0.74
Tacrolimus trough level 1M average before 3rd vaccine day (μg/L) [median (IQR)]	6.79 (5.6–7.7)	6.4 (5.8–7.6)	6.8 (5.4–7.9)	0.73
Mycophenolic acid (MPA), n (%)	79 (76.8)	13 (92.9)	63 (74.1)	0.12
MPA daily dose (mg) on 3rd vaccine date, [median (IQR)]	720 (360–720)	720 (360–720)	720 (0.0–720)	0.19
MPA daily dose (mg) per weight (kg) on 3rd vaccine date, [median (IQR)]	7.7 (3.6–9.5)	8.2 (5.1–10.3)	7.4 (0.0–9.2)	0.25
Prednisone, n (%)	74 (74.75)	10 (71.4)	64 (75.3)	0.76
Prednisone daily dose (mg) on 3rd vaccine date, [median (IQR)]	5.0 (0.0–5.0)	5.0 (0.0–5.0)	5.0 (3.0–5.0)	0.58
Prednisone daily dose (mg) per weight (kg) on 3rd vaccine date, [median (IQR)]	0.05 (0.00–0.07)	0.06 (0.00–0.06)	0.05 (0.03–0.07)	0.57
Immunosuppressive regimen
Tacrolimus + MPA + prednisone, n (%)	45 (45.5)	7 (50)	38 (44.7)	0.71
Tacrolimus + MPA, n (%)	22 (22.2)	4 (28.6)	18 (21.2)	0.54
Tacrolimus + prednisone, n (%)	16 (16.2)	1 (7.1)	15 (17.6)	0.32
Cyclosporine + MPA + prednisone, n (%)	5 (5.1)	1 (7.1)	4 (4.7)	0.7
Tacrolimus + azathioprine, n (%)	2 (2.02)	0 (0)	2 (2.4)	0.56
Tacrolimus + azathioprine + prednisone, n (%)	2 (2.02)	0 (0)	2 (2.4)	0.56
mTORi (everolimus or sirolimus), n (%)	5 (5.1)	0 (0)	5 (5.9)	0.35

Abbreviations: MPA, mycophenolic acid; mTORi- mammalian target of rapamycin inhibitor.