TABLE 3.
RBD IgG and NA prior to third vaccine and post third vaccine stratified by Antibody Response to third vaccine.
| Variable | Total cohort (N = 99) | Negative (N = 14) | Positive (N = 85) | p value |
|---|---|---|---|---|
| Baseline immune status on 3rd vaccine day | ||||
| Positive RBD IgG and NA on 3rd vaccine day, n (%) | 32 (32.3) | 1 (7.1) | 31 (36.5) | 0.03* |
| Negative RBD IgG and NA on 3rd vaccine day, n (%) | 67 (67.7) | 13 (92.9) | 54 (63.5) | 0.03* |
| IgG-RBD GMT on 3rd vaccine day (95% CI) | 0.79 (0.65–0.96) | 0.34 (0.23–0.51) | 0.91 (0.74–1.12) | 0.0005** |
| NA GMT on 3rd vaccine day, (95% CI) | 17.46 (12.38–24.62) | 6.56 (3.12–13.80) | 20.51 (14.1–29.85) | 0.02* |
| Response to 3rd vaccine | ||||
| IgG-RBD GMT post 3rd vaccine day (95% CI) | 3.08 (2.76–3.45) | 1.28 (0.87–1.86) | 3.57 (3.28–3.88) | <0.0001** |
| NA GMT post 3rd vaccine day (95% CI) | 362.2 (220.7–594.6) | 7.25 (2.42–21.71) | 689.9 (456.3–1043) | <0.0001** |
Abbreviations: CI, confidence intervals; GMT, geometric mean titer; NA, neutralizing antibodies; RBD, receptor-binding domain.
*<0.05, **<0.001.
When p value is significant, below 0.05 or below 0.01 the values are bolded.