TABLE 4.

Univariate Analysis for immune status before the third vaccine vs. post third vaccine in RTR.

	Before 3rd vaccine (N = 99)	Post 3rd vaccine (N = 99)	p value
All cohort
IgG-RBD GMT (95% CI)	0.79 (0.65–0.96)	3.08 (2.76–3.45)	<0.0001**
NA GMT (95% CI)	17.46 (12.38–24.62)	362.2 (220.7–594.6)	<0.0001**
Positive responders
n (%)	32 (32.3)	85 (85.9)	<0.0001**
IgG-RBD GMT (95% CI)	2.53 (2.07–3.11)	3.57 (3.28–3.88)	<0.0001**
NA GMT (95% CI)	89.12 (53.03–149.8)	689.9 (456.3–1043)	<0.0001**
Negative responders
n (%)	67 (67.7)	14 (14.14)	<0.0001**
IgG-RBD GMT (95% CI)	0.45 (0.39–0.52)	1.28 (0.87–1.86)	0.001*
NA GMT (95% CI)	8.01 (5.92–10.84)	7.25 (2.42–21.71)	0.85

Abbreviations: CI, confidence intervals; GMT, geometric mean titer; NA, neutralizing antibodies; RBD, receptor-binding domain.

* <0.05, ** <0.001.

When p value is significant, below 0.05 or below 0.01 the values are bolded.