. 2022 Apr 4;42(6):973–987. doi: 10.1007/s00296-022-05119-y

Table 5.

Clinical description of the flares among patients with Behçet’s syndrome, familial Mediterranean fever and rheumatic diseases after vaccination with CoronaVac and BioNTech

CoronaVac
Oral ulcers (n = 5) Erythema nodosum (n = 3) Papulopustular lesion (n = 1) Uveitis (n = 3) Upper extremity deep vein thrombosis (n = 1) Lower extremity deep vein thrombosis (n = 1) CNS parenchymal attack (n = 1)	Fever, peritonitis with or without diarrhea (n = 13) Peritonitis and pleuritis (n = 3) Pleuritis alone (n = 2) Fever attack with increased acute phase reactants (n = 4) Pain or swelling in the joints (n = 3)	Pain or swelling in the joints (RA: n = 6, AS: n = 3, SSc: n = 1, GCA: n = 1) Inflammatory back pain and stiffness (AS: n = 4) Psoriasis (PsA: n = 1) Digital ulcer (SSc: n = 1) Shoulder pain and stiffness (GCA-PMR: n = 1)

CoronaVac

Behçet’s syndrome, n = 12 (11.0%)

Familial Mediterranean fever, n = 22 (24.4%)

Rheumatic diseases, n = 18 (5.2%)

Oral ulcers (n = 5)

Erythema nodosum (n = 3)

Papulopustular lesion (n = 1)

Uveitis (n = 3)

Upper extremity deep vein thrombosis (n = 1)

Lower extremity deep vein thrombosis (n = 1)

CNS parenchymal attack (n = 1)

Fever, peritonitis with or without diarrhea (n = 13)

Peritonitis and pleuritis (n = 3)

Pleuritis alone (n = 2)

Fever attack with increased acute phase reactants (n = 4)

Pain or swelling in the joints (n = 3)

Pain or swelling in the joints (RA: n = 6, AS: n = 3, SSc: n = 1, GCA: n = 1)

Inflammatory back pain and stiffness (AS: n = 4)

Psoriasis (PsA: n = 1)

Digital ulcer (SSc: n = 1)

Shoulder pain and stiffness (GCA-PMR: n = 1)

BioNTech
Oral ulcers (n = 19) Genital ulcers (n = 3) Erythema nodosum (n = 2) Uveitis (n = 2) Papulopustular lesion (n = 10) Lower extremity deep vein thrombosis (n = 3) Epididymitis (n = 1) Bouts of hemoptysis (n = 1) Pain or swelling in the joints (n = 7) Peritonitis attack due to concomitantly present FMF (n = 1)	Fever, peritonitis with or without diarrhea (n = 8) Peritonitis and pleuritis (n = 5) Pleuritis alone (n = 2) Fever attack with increased acute phase reactants (n = 6) Pain or swelling in the joints (n = 7) Development of hidradenitis suppurativa lesions (n = 1)	Pain or swelling in the joints (RA: n = 5, SSc: n = 1, pSA: n = 3) Myastenia gravis (n = 1) Raynaud and digital ulcers (SSc: n = 1) Inflammatory back pain (AS: n = 6, pSA: n = 1) Emergence of small vessel vasculitis (AS: n = 1) Stroke (TAK: n = 1) Myocardial ischemia (TAK: n = 1)

BioNTech

Behçet’s syndrome, n = 29 (19.7%)

Familial Mediterranean fever, n = 21 (13.4%)

Rheumatic diseases, n = 18 (7.0%)

Oral ulcers (n = 19)

Genital ulcers (n = 3)

Erythema nodosum (n = 2)

Uveitis (n = 2)

Papulopustular lesion (n = 10)

Lower extremity deep vein thrombosis (n = 3)

Epididymitis (n = 1)

Bouts of hemoptysis (n = 1)

Pain or swelling in the joints (n = 7)

Peritonitis attack due to concomitantly present FMF (n = 1)

Fever, peritonitis with or without diarrhea (n = 8)

Peritonitis and pleuritis (n = 5)

Pleuritis alone (n = 2)

Fever attack with increased acute phase reactants (n = 6)

Pain or swelling in the joints (n = 7)

Development of hidradenitis suppurativa lesions (n = 1)

Pain or swelling in the joints (RA: n = 5, SSc: n = 1, pSA: n = 3)

Myastenia gravis (n = 1)

Raynaud and digital ulcers (SSc: n = 1)

Inflammatory back pain (AS: n = 6, pSA: n = 1)

Emergence of small vessel vasculitis (AS: n = 1)

Stroke (TAK: n = 1)

Myocardial ischemia (TAK: n = 1)

RA rheumatoid arthritis, BS Behçet’s syndrome, PsA psoriasis, FMF familial Mediterranean fever, CNS central nervous system, GCA giant cell arteritis, PMR polymyalgia rheumatica, pSA psoriatic arthritis, SSc systemic sclerosis, TAK Takayasu arteritis