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. 2022 Mar 21;13:818522. doi: 10.3389/fneur.2022.818522

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Copyright © 2022 Ling, Chen, He, Feng, Weng, Cheng, Rong and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network meta-analysis of eligible comparisons for secondary outcomes. (A) Pain relief more than 8 weeks, n = 615. (B) Mental or sleep-related symptom relief, n = 825. (C) Serious adverse events, n = 1,232. Width of the lines is proportional to the number of trials, comparing every pair of treatments for secondary outcomes (numbers on the lines). Size of every circle is proportional to the number of randomly assigned participants (sample size). BTX-A, botulinum toxin-A; Ket, ketamine; Ami, amitriptyline; Lam, lamotrigine; Pre, pregabalin; Dul, duloxetine; Gab, gabapentin; Tra, tramadol; Lev, levetiracetam; Car, carbamazepine; Can, cannabinoids; Pla, placebo.