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. 2022 Mar 21;13:818522. doi: 10.3389/fneur.2022.818522

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Copyright © 2022 Ling, Chen, He, Feng, Weng, Cheng, Rong and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy pairwise and network meta-analysis of 11 drugs and placebo from 20 RCTs. A forest plot (A) shows pairwise and network meta-analysis of different drugs on the target of neuropathic pain relief after SCI as compared with placebo. And the forest plot (B) shows pairwise and network meta-analysis among head-to-head drugs. The blue line in forest plots indicates the outcome analysis of corresponding studies, the green line refers to pooled within designed treatments, the red line means pooled overall. The test of consistency reveals all studies are according to the consistency model. BTX-A, botulinum toxin-A; Ket, ketamine; Ami, amitriptyline; Lam, lamotrigine; Pre, pregabalin; Dul, duloxetine; Gab, gabapentin; Tra, tramadol; Lev, levetiracetam; Car, carbamazepine; Can, cannabinoids; Pla, placebo.