TABLE 1.

Predicted peak and trough concentrations and pharmacodynamic parameters^a

Parameter and concentration	3.3 mg/kg q8h	5 mg/kg q12h	10 mg/kg q24h
Peak concn (μg/ml)	11.6 ± 2.6bc	16.4 ± 3.8bd	29.3 ± 6.9cd
Trough concn (μg/ml)	1.1 ± 0.9bc	0.4 ± 0.7bd	0.0 ± 0.2cd
MIC, 1 μg/ml
Peak/MIC	11.6 ± 2.6bc	16.4 ± 3.8bd	29.3 ± 6.9cd
T<MIC	0.0 ± 0.6bc	2.6 ± 1.7bd	12.5 ± 3.4cd
AUC/MIC	110.5 ± 31.7	111.5 ± 32.3	110.5 ± 32.3
MIC, 2 μg/ml
Peak/MIC	5.8 ± 1.3bc	8.2 ± 1.9bd	14.7 ± 3.5cd
T<MIC	2.0 ± 1.2bc	4.9 ± 1.9bd	14.6 ± 2.7cd
AUC/MIC	55.3 ± 15.9	57 ± 16.1	55.2 ± 16.1
MIC, 4 μg/ml
Peak/MIC	2.9 ± 0.7bc	4.1 ± 1.0bd	7.3 ± 1.7cd
T<MIC	4.2 ± 1.4bc	7.1 ± 1.5bd	16.8 ± 1.9cd
AUC/MIC	27.6 ± 8.0	28.5 ± 8.1	27.6 ± 8.1

^aValues are medians ± SDs. 

^bP < 0.001. 

^cP < 0.001. 

^dP < 0.001.