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Percentages of peripheral blood CD8+ T-cells expressing PD-1/Tim-3 in patients infected with either NS31073 prototype (GenBank EU255962.1) or variant epitope sequence as the dominant strain (upper panel). Lower panel shows intrahost aminoacid variability of this epitope where no variability denotes the presence of a single variant and variability indicates ≥ 2 variant sequences. Horizontal lines represent median values. Numbers above each bracket express P values.
