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Percentages of peripheral blood HCV-specific CD8+ T-cells expressing PD-1 and Tim-3 in 40 HLA-A*02-positive patients harboring NS31406 prototype (GenBank EU255962.1) or variant epitope sequence as the dominant strain (upper panel). Lower panel shows intrahost aminoacid variability of this epitope where no variability denotes the presence of a single variant and variability indicates ≥ 2 variant sequences. Horizontal lines represent median values.
