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. 2022 Mar 21;12:853755. doi: 10.3389/fonc.2022.853755

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Copyright © 2022 Wu, Raz, Recouvreux, Diniz, Lester, Karlan, Walts, Gertych and Orsulic

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fallopian tubes with STIC lesions exhibit a higher relative number of SCE as well as a higher number of secretory cells within SCE. (A) The relative number of SCE (number of SCE divided by the total number of epithelial cells in all ROIs on the slide). (B) The average number of secretory cells within SCE. Statistically significant differences were determined using the Kruskal-Wallis test; *P < 0.05; **P < 0.01; ****P < 0.0001. Benign: fallopian tubes from women with benign gynecologic conditions. NoSTIC: fallopian tubes without STIC lesions from women with HGSOC. STIC: fallopian tubes with STIC lesions from women with HGSOC.