TABLE 1.
Variations of R-6.
| R-6 | Formulation 1 | Formulation 2 | Formulation 3 | Formulation 4 | Formulation 5 |
| Rehmanniae Radix (Di-huang) | Rehmanniae Radix (Di-huang) | Rehmanniae Radix (Di-huang) | Rehmanniae Radix (Di-huang) | Rehmanniae Radix (Di-huang) | Rehmanniae Radix (Di-huang) |
| Dioscoreae Rhizoma (Shan-yao) | Dioscoreae Rhizoma (Shan-yao) | Dioscoreae Rhizoma (Shan-yao) | Dioscoreae Rhizoma (Shan-yao) | Dioscoreae Rhizoma (Shan-yao) | Dioscoreae Rhizoma (Shan-yao) |
| Corni Fructus (Shan-zhu-yu) | Corni Fructus (Shan-zhu-yu) | Corni Fructus (Shan-zhu-yu) | Corni Fructus (Shan-zhu-yu) | Corni Fructus (Shan-zhu-yu) | Corni Fructus (Shan-zhu-yu) |
| Moutan Cortex (Mu-dan-pi) | Moutan Cortex (Mu-dan-pi) | Moutan Cortex (Mu-dan-pi) | Moutan Cortex (Mu-dan-pi) | Moutan Cortex (Mu-dan-pi) | Moutan Cortex (Mu-dan-pi) |
| Poria (Fu-ling) | Poria (Fu-ling) | Poria (Fu-ling) | Poria (Fu-ling) | Poria (Fu-ling) | Poria (Fu-ling) |
| Alismatis Rhizoma (Ze-xie) | Alismatis Rhizoma (Ze-xie) | Alismatis Rhizoma (Ze-xie) | Ginseng Radix et Rhizoma (Ren-shen) | Alismatis Rhizoma (Ze-xie) | Alismatis Rhizoma (Ze-xie) |
| Aucklandiae Radix (Mu-xiang) | Chaenomelis Fructus (Mu-gua) | Astragali Radix (Huang-qi) | Ligustri Lucidi Fructus (Nv-zhen-zi) | Cinnamomi Ramulus (Gui-zhi) | |
| Amomi Fructus (Sha-ren) | Aucklandiae Radix (Mu-xiang) | Zingiberis Rhizoma Recens (Sheng-jiang) | Eclipta prostrata (Mo-Han-Lian) | Aconiti Lateralis Radix Praeparata (Fu-zi) | |
| Citri Reticulatae Pericarpium (Chen pi) | Arecae Semen (Bing-lang) | Jujubae Fructus (Da-zao) | Ligustri Lucidi Fructus (Nv-zhen-zi) | ||
| Ginseng Radix et Rhizoma (Ren-shen) | Aconiti Lateralis Radix Praeparata (Fu-zi) | ||||
| Pinelliae Rhizoma (Ban-xia) | Zingiberis Rhizoma (Gan-jiang) | ||||
| Atractylodis Macrocephalae Rhizoma (Bai-zhu) | Glycyrrhizae Radix et Rhizoma (Gan-cao) | ||||
| Glycyrrhizae Radix et Rhizoma (Gan-cao) | Zingiberis Rhizoma Recens (Sheng-jiang) | ||||
| Jujubae Fructus (Da-zao) | |||||
| Tsaoko Fructus (Cao-guo) |
Rehmannia-6 complex (R-6, Liu-wei-di-huang-wan) was the most used Chinese medicine formulation in the cohorts showing beneficial effect on diabetic kidney disease. Variations of R-6 were identified from a published existing clinical practice guideline developed from expert consensus and pilot clinical service program, which is undergoing a randomized clinical trial for evaluation.