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. 2022 Mar 21;13:868958. doi: 10.3389/fimmu.2022.868958

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Copyright © 2022 Thomas, Leleu and Masson

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIF-1α and hypoxia alter lipid homeostasis in macrophages. Activation of HIF-1α dependent pathways promotes triglyceride and cholesterol accumulation in macrophages through activation of lipogenesis, cholesterol synthesis and decrease of fatty acid oxidation. Hypoxia and HIF-1α also promotes low density lipoproteins (LDL) retention as well as oxidized LDL uptake by changing proteoglycan composition and increasing the expression of several scavenger receptors. Finally, in murine macrophages hypoxia/HIF-1α impair cholesterol efflux by altering ABCA1 localization.