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. 2022 Mar 21;13:838869. doi: 10.3389/fgene.2022.838869

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Copyright © 2022 Chen, Zhang, Ding and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSEA analysis of GINS1 (A) and conceptual map of the mechanism of ZFAS1/hsa-miR-150-5p/GINS1 axis (B). In the cytoplasm of HCC cell, lncRNA ZFAS1 could act as a sponge to bind and negatively regulate the expression of miRNA hsa-miR-150-5p. Then miR-150-5p-mediated suppression of target mRNA was relieved and GINS1 continued to exert an oncogenic role in the development of HCC. GSEA, gene set enrichment analysis; HCC, hepatocellular carcinoma; lncRNA, long non-coding RNA; miRNA, microRNA; mRNA, messenger RNA; KEGG, Kyoto Encyclopedia of Genes and Genomes; (+), upregulated; (−), downregulated.