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. 2022 Mar 21;13:838869. doi: 10.3389/fgene.2022.838869

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Copyright © 2022 Chen, Zhang, Ding and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of ceRNA prediction and ceRNA network construction. (A) Venn diagram of the common predicted lncRNAs. (B−F) Differential expression analysis of the lncRNAs in GEPIA. Tumor tissue is shown in red, and normal tissue is shown in gray. (G) Venn diagram of the predicted circRNAs and differentially expressed circRNAs. Sankey diagrams of the lncRNA-miRNA-mRNA regulatory relationship (H) and circRNA-miRNA-mRNA regulatory relationship (I). (J) The ceRNA network. Red represents the mRNAs, blue represents the miRNAs, green represents the lncRNAs, and yellow represents the circRNAs. CeRNA, competing endogenous RNA; lncRNA, long non-coding RNA; GEPIA, Gene Expression Profiling Interactive Analysis; circRNA, circular RNA; miRNA, microRNA; mRNA, messenger RNA; LIHC, liver hepatocellular carcinoma; T, tumor; N, normal; DE_circRNA, differentially expressed circular RNA.