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. 2022 Mar 21;15:822458. doi: 10.3389/fnmol.2022.822458

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Copyright © 2022 Mo, Liu, Gong, Mei, Chen, Mo, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Higher concentration of Zn²⁺ damages the excitatory synaptic transmission. (A) Sample traces of mEPSCs recorded in cortical neurons cultured with 0 μM/10 μM/50 μM Zn²⁺. (B) Summary graphs of the normalized frequency of mEPSCs for all conditions as described for (A). (C) Sample trace of action potential eEPSCs recorded from cortical neurons cultured with 0 μM/10 μM/50 μM Zn²⁺. (D) Summary graphs of the normalized amplitude of eEPSCs recorded in the neurons described in panel (C). Data information: numbers of cells/independent cultures analyzed are listed in the bars. Data shown in summary graphs are mean values ± SEM. Statistical significance was analyzed by Student’s t-test. **p < 0.01; ***p < 0.001.