Figure 5.

PTPRM is key for excitatory synaptic signal transduction mediated by Zn²⁺. (A) Representative traces of mEPSCs recorded in cortical neurons overexpressed PTPRM or not cultured with/without 50 μM Zn²⁺ when expressed PTPRM or not. (B) Summary graphs of the normalized frequency of mEPSCs for all conditions as described in panel (A). (C) Statistical summary of the normalized amplitude of mEPSCs for all conditions as described in panel (A). (D) Representative of eEPSCs recorded from cortical neurons described in panel (A). (E) Statistical summary of normalized amplitude of eEPSCs recorded in the neurons described in panel (A). Data information: numbers of cells/independent cultures analyzed are listed in the bars. Data shown in summary graphs are mean values ± SEM. Statistical significance was analyzed by Student’s t-test. *p < 0.05.