TABLE 1.
Drug | MIC (μg/ml) | Dose (μg/ml) | Drug effect
|
|
---|---|---|---|---|
MP | Permeability | |||
Amoxicillin | 1.0 | 0.25, 0.5 | Little or no change | At 2 h, 33% permeabilized; at 3 to 4 h, <8% permeabilized |
1.0 | At 3 h, >99% depolarized | At 3 h, 69% permeabilized | ||
4.0 | At 3 h, >99% depolarized | At 3 h, 29% permeabilized | ||
Chloramphenicol | NDa | 4.0b | No change after 4 h | No change after 4 h |
Erythromycin | 4.0 | <1.0 | No change after 4 h | No change after 4 h |
4.0 | Depolarization by 4 h | 20% permeabilized at 4 h | ||
Streptomycin | ND | 5.0b | Depolarization by 1 h | No change after 4 h |
Tetracycline | 0.25 | <1.0 | No change after 4 h | No change after 4 h |
4.0 | Depolarization by 4 h | 50% permeabilized at 4 h |
ND, not determined.
The dose completely inhibited bacterial growth.