Table 3.
Subgroup analysis and test for effect modification for the association between fibrinogen and the risk of coronary artery disease, according to age, sex and smoking status
| n | Q1 | Q2 | Q3 | Q4 | Trend test | P for interaction | |
| HR | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| CAD | |||||||
| Age | 0.75 | ||||||
| Age <65 | 1757 | 1 | 0.84 (0.45 to 1.56) | 0.93 (0.51 to 1.69) | 1.33 (0.75 to 2.34) | 0.22 | |
| Age ≥65 | 465 | 1 | 1.28 (0.34 to 4.86) | 0.99 (0.25 to 3.87) | 2.85 (0.82 to 9.88) | 0.013 | |
| Sex | 0.46 | ||||||
| Men | 1036 | 1 | 0.99 (0.47 to 2.09) | 1.21 (0.59 to 2.52) | 1.69 (0.85 to 3.37) | 0.059 | |
| Women | 1186 | 1 | 0.77 (0.34 to 1.74) | 0.53 (0.23 to 1.23) | 1.33 (0.64 to 2.77) | 0.33 | |
| Smoking | 0.52 | ||||||
| Smoking (−) | 1448 | 1 | 0.81 (0.41 to 1.60) | 0.71 (0.35 to 1.46) | 1.08 (0.56 to 2.11) | 0.74 | |
| Smoking (+) | 774 | 1 | 1.06 (0.42 to 2.68) | 1.17 (0.48 to 2.83) | 2.21 (0.98 to 4.97) | 0.011 | |
| All-cause death | |||||||
| Age | <0.001 | ||||||
| Age <65 | 1757 | 1 | 0.92 (0.68 to 1.23) | 1.00 (0.74 to 1.34) | 1.47 (1.11 to 1.95) | 0.004 | |
| Age ≥65 | 465 | 1 | 0.66 (0.46 to 0.95) | 0.81 (0.57 to 1.15) | 0.99 (0.70 to 1.39) | 0.14 | |
| Sex | 0.61 | ||||||
| Men | 1036 | 1 | 0.83 (0.62 to 1.12) | 0.80 (0.59 to 1.09) | 1.07 (0.81 to 1.42) | 0.29 | |
| Women | 1186 | 1 | 0.71 (0.49 to 1.03) | 0.89 (0.64 to 1.26) | 1.12 (0.80 to 1.58) | 0.12 | |
| Smoking | 0.88 | ||||||
| Smoking (−) | 1448 | 1 | 0.79 (0.58 to 1.08) | 0.91 (0.67 to 1.24) | 1.16 (0.86 to 1.58) | 0.09 | |
| Smoking (+) | 774 | 1 | 0.77 (0.55 to 1.07) | 0.77 (0.56 to 1.07) | 1.03 (0.76 to 1.40) | 0.33 | |
*Adjusted for sex, age, body mass index, smoking, drinking, regular exercise, hypertension, diabetes mellitus, triglycerides, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and glucose.
CAD, coronary artery disease; CI, confidence interval; HR, hazard ratio.