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. 2022 Mar 31;10(2):e002699. doi: 10.1136/bmjdrc-2021-002699

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Trimetazidine (TMZ) regulates the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathway and resists oxidative stress reaction induced by palmitate (PA). PA, skeletal muscle cells treated with palmitate; siNC, treated with negative control small interfering RNA; siNrf2, treated with Nrf2 small interfering RNA; TMZ, skeletal muscle cells treated with TMZ. (A, B) Nrf2 protein expression was determined by western blot. (C, D) DCF: DCFH-DA (2,7-dichlorodihydrofluorescein diacetate), dihydroethidium (DHE) were detected for reactive oxygen species. *,**Represented p<0.05, p<0.01 in comparison with siNC group, respectively; ^#, ^##represented p<0.05, p<0.01 in comparison with PA+siNC group, respectively; ^@,^@@represented p<0.05, p<0.01 in comparison with PA+TMZ+siNC group, respectively. GAPDH, glyceraldehyde-3-phosphate dehydrogenase.