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. 2022 Mar 21;13:840134. doi: 10.3389/fphar.2022.840134

FIGURE 5.

FIGURE 5

Treatment with SCH58261 decreased number of apoptotic nuclei and GFAP immunoreactive areas. (A,B) Representative section showing TUNEL staining of ONL of retina of a CTL eye (A) and an SCH58261-treated eye (B). Treated eyes had a lower number of apoptotic nuclei than controls. Scale bar: 20 μm. (C,D) GFAP-immunostained section from retina of a CTL eye (C) and an SCH58261-treated eye (D). Less GFAP immunoreactivity of Müller cells is observed in retina of SCH58261-treated eye compared with CTL. (E). Quantification of TUNEL-positive ONL cells. SCH58261 produced a significant decrease in number of positive nuclei in ONL compared with CTL. Student’s t-test, *p < 0.05. (F) Quantification of GFAP immunoreactive area. SCH58261 produced a significant decrease in GFAP expression compared with CTL. Boxes represent 25 and 75 percentiles, whiskers represent minimum and maximum values, and transverse lines represent medians.