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. 2022 Jan 21;13(2):1177–1196. doi: 10.1002/jcsm.12887

Figure 7.

Figure 7

Cholesterol and lipid mediators are differentially altered in P7C3 treated db/db mice. (A) high‐density lipoprotein, (B) low‐density lipoprotein/very low‐density lipoprotein ratio. Panels (C–H) lipid mediators measured in wild‐type (WT), db‐Veh and db‐P7C3 treated mice, where (C) arachidonic acid; AA, (D) docosahexaenoic acid; DHA, (E) Eicosapentaenoic acid; EPA, (F) heat map of the pro‐inflammatory AA derivatives HETEs, and the anti‐inflammatory DHA derivatives HDoHEs and the EPA derivative HEPE (G) endocannabinoids, 2‐arachidonoylglycerol; 2‐AG and (H) anandamide; AEA. (I) Levels of serum IP‐10 (C‐X‐C motif chemokine ligand 10) measured by Luminex‐MagPix magnetic bead immunoassay. Data are expressed as mean ± SEM; *P < 0.05. The age‐matched WT mice were used as naïve control to determine the baseline lipid mediators levels in gastrocnemius muscle.