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Figure shows the upregulation of BACE1 and BACE1-AS in cancer tissues and cells suggesting them with oncogenic functions. BACE1 and lncRNA BACE1-AS have also been found in association with progression for several cancers and neurodegenerative diseases. Pharmacological inhibition of BACE1 using MK-8931 causes reprogramming of pTAMs into sTAMs and suppression of tumor growth in glioblastoma.
