Table 2.

Biochemical Characteristics of Genetically Confirmed HHRH Cohort

Biochemical Features		P Value
eGFR,a mL/min/1.73 m2, median (Q1, Q3)	68.5 (55.0, 81.5)	0.14
eGFR children, median (Q1, Q3)	76 (72.0, 98.0)
eGFR adult, median (Q1, Q3)	64.0 (50.0, 69.0)
Serum Ca, mg/dL, median (Q1, Q3)	9.9 (9.7, 10.1)	0.59
Children, median (Q1, Q3)	9.8 (9.7, 9.9)
Adult, median (Q1, Q3)	9.9 (9.7, 10.2)
Serum Pi, mg/dL, median (Q1, Q3)	3.1 (2.9, 3.7)	0.84
Children, median (Q1, Q3)	3.1 (2.9, 4.3)
Adult, median (Q1, Q3)	33.0 (2.9, 3.4)
iPTH, pg/dL, median (Q1, Q3)	13.5 (9.1, 25.5)	0.35
Children, median (Q1, Q3)	13.0 (8.1, 15.0)
Adult, median (Q1, Q3)	14.0 (10.0, 26.0)
1,25(OH)2D, pg/dL, median (Q1, Q3)	75.0 (41.6, 99.0)	0.009
Children, median (Q1, Q3)	160.0 (491.9, 178.0)
Adult, median (Q1, Q3)	63.0 (40.2, 80.0)
25(OH)D, ng/dL, median (Q1, Q3)	29.0 (21.8, 45.5)	0.76
Children, median (Q1, Q3)	22.0 (20.0, 52.0)
Adult, median (Q1, Q3)	30.0 (25.0, 39.0)
Pi, 24U, mg/d, adult
Median (Q1, Q3)	780.0 (700.0, 901.0)
Ca, 24U, mg/d, adult
Median (Q1, Q3)	315.0 (273.0, 331.0)
Ca, 24U, mg/k/d, children
Median (Q1, Q3)	5.9 (4.5, 7.2)
Pi, 24U, mg/k/d, children
Median (Q1, Q3)	14.0 (14.0, 14.1)

Note: A normal eGFR value is ≥90; a normal Pi value is 3.5-5.4 mg/dL in children and 2.5-4.5 mg/dL in adults; a normal iPTH value is 15-65 pg/dL; a normal 1,25(OH)₂D value is 16-65 pg/dL; and a normal 25(OH)D value is 20-50 ng/dL. Conversion factors for units: SCa in mg/dL to mmol/L, ×0.2495; SPi in mg/dL to mmol/L, ×0.3229; iPTH in pg/mL to pmol/L, ×0.106; 1,25(OH)₂D in pg/dL to pmol/L, ×2.6; and 25(OH)D in ng/dL to nmol/L, ×2.496.

Abbreviations: Ca, calcium; eGFR, estimated glomerular filtration rate; HHRH, hypophosphatemic rickets and hypercalciuria; iPTH, intact parathyroid hormone; Pi, inorganic phosphorus; 25(OH)D, 25-hydroxyvitamin D; 24U, 24-hour urine output.

^aBiochemical data were obtained at the time of HHRH evaluation.