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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Exp Neurol. 2021 Jul 24;345:113816. doi: 10.1016/j.expneurol.2021.113816

Figure 3. MN72 prevents reductions in CA3 and CA1 neuronal volume and dendritic field size induced by CHI.

Figure 3

A, D, Polygons generated to assess CA3 (A) and CA1 (D) neuron volume and dendritic field size. B, CHI bilaterally reduced CA3 neuron volume which was prevented by MN72 in the contralateral hippocampus. C, CHI reduced contralateral CA3 basal dendritic field size and bilaterally reduced CA3 apical dendritic field size. MN72 prevented reduction of CA3 dendritic field size only in contralateral apical dendrites. E, CHI bilaterally reduced CA1 neuron volume which was prevented by MN72. F, MN72 bilaterally maintained CA1 basal and apical dendritic field sizes. An asterisk (*) represents significant difference with Sham-CHI, a hashtag (#) represents significant differences with CHI-MN72. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.