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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Exp Neurol. 2021 Jul 24;345:113816. doi: 10.1016/j.expneurol.2021.113816

Figure 7. MN72 maintains spine density in CA1 apical dendrites.

Figure 7

A-B, Representative images of proximal (A) and distal (B) Golgi-Cox stained CA1 apical dendrites. C, Summary of differences in total spine density. CHI bilaterally reduced total spine density in proximal and distal dendritic regions, which was maintained bilaterally by MN72. D, Individual spine type density in proximal dendrites. CHI bilaterally reduced proximal mushroom spine density. MN72 treatment maintained mushroom spine density. E, Individual spine type density in distal dendrites. CHI bilaterally reduced distal mushroom spine density. MN72 treatment maintained distal mushroom spine density in the contralateral hippocampus. An asterisk (*) represents significant a difference with Sham-CHI, a hashtag (#) represents a significant difference with CHI-MN72; *p < 0.05, ** p < 0.01, *** p < 0.001, ****p < 0.0001. Scale bar, 2μm.