TABLE 1.
Parameters of Interest for Typical Oncologic Models
| Model type | Parameter of interest |
|---|---|
| Microparameters | |
| 1-tissue-compartment model | K1 (blood-tissue transfer constant), k2 (tissue-blood transfer content), |
| 2-tissue-compartment model | K1, k2, k3 (representing substrate-target binding or metabolism rate constant), k4 (off-binding or metabolic degradation rate constant) |
| Macroparameters | |
| VT (1-tissue compartment) | VT = K1/k2 |
| VT (2-tissue compartments) | VT = (K1/k2) × (1 + [k3/k4]) |
| Ki | Ki = K1k2/(k2 + k3) |
| Typical units | |
| K rate constant | mL/min/cm3 |
| k rate constant | 1/min |
| VT | mL/cm3 |