Fig. 7.

Effects of PPI analysis. A) Regions with altered connectivity to the right somatosensory cortex as a function of mood context (sad vs. neutral). Orange areas are FWE-corrected positive PPI score areas, whereas blue areas are negative scores. B) Sadness-evoked connectivity change with the right lateral prefrontal cortex (LPFC) is significantly related to future relapse status. C) Connectivity between the somatosensory cortex and right LPFC is responsive to dysphoric mood induction. D) The magnitude of sadness-evoked deactivation between right LPFC and somatosensory cortex distinguishes relapsers from non-relapsers. Interpretation of how this connectivity relates to the right somatosensory seed region may be challenging given that main effect within the somatosensory region was a deactivation; by this logic, orange areas were more negatively associated with the somatosensory cortex during sad-mood induction, whereas blue areas were more positively associated with the somatosensory cortex, sharing in the deactivation pattern. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)