Table 1.
Diagnostic specificity, sensitivity, and AUC values of 17 DEGs as determined by ROC analysis
| Genes | Threshold a | Specificity, % | Sensitivity, % | AUC | AUC 95% CI |
|---|---|---|---|---|---|
| ADAMDEC1 | 7.1 | 97.8 | 100.0 | 0.999 | 0.996–1 |
| RASGRP1 | 6.5 | 97.8 | 91.2 | 0.987 | 0.972–1 |
| GZMB | 6.7 | 93.4 | 94.7 | 0.982 | 0.964–1 |
| CXCL13 | 7.5 | 91.3 | 91.2 | 0.946 | 0.903–0.989 |
| GPR1 | 6.7 | 97.8 | 75.4 | 0.939 | 0.898–0.980 |
| IL7R | 8.4 | 87.0 | 87.7 | 0.918 | 0.863–0.971 |
| CCL18 | 10.8 | 87.0 | 86.0 | 0.903 | 0.845–0.961 |
| CD247 | 7.7 | 84.8 | 87.7 | 0.895 | 0.830–0.961 |
| GCH1 | 8.6 | 95.0 | 71.9 | 0.895 | 0.840–0.954 |
| QPCT | 7.2 | 91.3 | 84.2 | 0.895 | 0.831–0.959 |
| GZMH | 8.3 | 87.0 | 84.2 | 0.889 | 0.812–0.966 |
| ZIC1 | 10.6 | 87.0 | 94.7 | 0.877 | 0.794–0.960 |
| CXCL10 | 9.4 | 91.3 | 75.4 | 0.869 | 0.798–0.940 |
| SCRG1 | 8.9 | 87.0 | 79.0 | 0.858 | 0.776–0.939 |
| CD3D | 9.2 | 91.3 | 75.4 | 0.857 | 0.782–0.933 |
| TNFAIP3 | 9.3 | 89.1 | 86.0 | 0.832 | 0.743–0.920 |
| SEL1L3 | 9.2 | 87.0 | 75.4 | 0.812 | 0.720–0.901 |
AUC area under the curve, CI confidence interval, ADAMDEC1 ADAM Like Decysin 1, CD247 T-Cell Surface Glycoprotein CD3 Zeta Chain, CD3D T‑cell surface glycoprotein CD3 δ chain, CXCL10 C-X-C Motif Chemokine Ligand 10, CXCL13 C-X-C Motif Chemokine Ligand 13, GCH1 GTP Cyclohydrolase 1, GPR1 G Protein-Coupled Receptor 1, GZMB Granzyme B, GZMH Granzyme B, IL7R interleukin 7 receptor, QPCT Glutaminyl-Peptide Cyclotransferase, RASGRP1 RAS Guanyl Releasing Protein 1, SCRG1 Stimulator Of Chondrogenesis 1, SEL1L3 SEL1L Family Member 3, TNFAIP3 TNF Alpha Induced Protein 3, ZIC1 Zic Family Member 1
afold changes in RA compared with OA tissue