Table 2.

GO enrichment analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis

ID	GO term description	P	Genes
Biological processes (BPs)
GO:0,060,326	chemotaxis, cell migration	0.015	CCL18/CXCL10/CXCL13
GO:0,001,906	cytotoxicity, cell killing	0.022	GZMB/IL7R/RASGRP1/GZMH
GO:0,002,544	inflammatory response	0.022	CXCL13/TNFAIP3/CD247/CCL18/GCH1
GO:0,071,216	response to stimulus	0.014	CXCL10/CXCL13/GCH1/TNFAIP3
GO:0,030,217	T cell differentiation, cell mediated immunity	0.023	CD3D/IL7R/RASGRP1/CXCL13/TNFAIP3/GZMB
Molecular functions (MFs)
GO:0,008,009	chemokine activity	< 0.001	CCL18/CXCL10/CXCL13
GO:0,042,379	chemokine receptor binding	0.001	CCL18/CXCL10/CXCL13
GO:0,045,236	CXCR chemokine receptor binding	0.001	CXCL10/CXCL13
GO:0,048,020	CCR chemokine receptor binding	0.013	CCL18/CXCL13
GO:0,005,125	cytokine activity	0.014	CCL18/CXCL10/CXCL13
GO:0,001,664	G protein-coupled receptor binding	0.022	CCL18/CXCL10/CXCL13
GO:0,005,126	cytokine receptor binding	0.022	CCL18/CXCL10/CXCL13
Cellular component (CCs)
GO:0,030,665	clathrin-coated vesicle membrane	0.036	CD3D/IL7R
GO:0,009,897	external side of plasma membrane	0.036	CD3D/CXCL10/IL7R
GO:0,042,101	T cell receptor complex	0.036	CD247/CD3D
GO:0,044,306	neuron projection terminus	0.036	GCH1/SCRG1
GO:0,030,662	coated vesicle membrane	0.043	CD3D/IL7R
GO:0,030,136	clathrin-coated vesicle	0.043	CD3D/IL7R

GO Gene Ontology, ADAMDEC1 ADAM Like Decysin 1, CD247 T-Cell Surface Glycoprotein CD3 Zeta Chain, CD3D T‑cell surface glycoprotein CD3 δ chain, CXCL10 C-X-C Motif Chemokine Ligand 10, CXCL13 C-X-C Motif Chemokine Ligand 13, GCH1 GTP Cyclohydrolase 1, GPR1 G Protein-Coupled Receptor 1, GZMB Granzyme B, GZMH Granzyme B, IL7R interleukin 7 receptor, QPCT Glutaminyl-Peptide Cyclotransferase, RASGRP1 RAS Guanyl Releasing Protein 1, SCRG1 Stimulator Of Chondrogenesis 1, SEL1L3 SEL1L Family Member 3, TNFAIP3 TNF Alpha Induced Protein 3, ZIC1 Zic Family Member 1