FIG. 4.

In vivo effects in mice of a single oral dose (400 mg/kg) of pefloxacin on proteoglycan synthesis as indicated by changes in ³⁵S incorporation 48 h after pefloxacin administration and 24 h after intraperitoneal administration of ³⁵S (2 μCi/g). Control animals received saline only. Values are percent differences in ³⁵S incorporation in treated mice and controls (n = 2 experiments each with five mice). B, blood; AT, Achilles tendon. ∗, P < 0.05, and ∗∗, P < 0.01, versus controls (Student's t test).