Table 3.

Effects of the MS-PRS (P_T < 0.01) on the number of potholes and molehills. (n = 1087).

Outcome, minimum voxel cluster size in mm3	MS-PRS (PT < 0.01)
	β	SE	ΔR2	p	FDR
Potholes
25	−0.7	0.45	0.0021	1.18×10−1	1.35 × 10−1
50	−0.6	0.29	0.0034	4.90×10−2	6.84 × 10−2
100	−0.3	0.17	0.0034	5.13×10−2	6.84 × 10−2
200	−0.1	0.09	0.0016	1.86×10−1	1.86 × 10−1
Molehills
25	1.5	0.48	0.0082	2.29×10−3	9.15 × 10 −3
50	0.9	0.29	0.0085	1.97×10−3	9.15 × 10 −3
100	0.4	0.16	0.0060	9.79×10−3	1.96 × 10 −2
200	0.3	0.09	0.0077	3.53×10−3	9.43 × 10 −3

FDR: False Discovery Rate; MS: multiple sclerosis; PRS: polygenic risk score; SE: standard error. Included: n = 1087 children, data are corrected for age, sex, and 10 genetic principal components (PCs). Significant values after FDR multiple testing correction are highlighted in bold.