Table 3.
Wnt‐related pathways are enriched in HEMOHigh tumors in TCGA cohorts. For each TCGA cohort, normalized enrichment score (NES, bold) and adjusted P‐value (in brackets) of GSEA (performed on Gene Ontology Biological Process and REACTOME databases) are given when the Wnt‐related pathway is significantly enriched. RESP., respiratory; Green: terms illustrated on enrichment plots of Fig. 5B and Fig. S4A.
| RESP. | FEMALE | DIGESTIVE | URINARY | ||||
|---|---|---|---|---|---|---|---|
| LUSC | BRCA | UCEC | CESC | COAD | BLCA | ||
| GO canonical Wnt signaling pathway* | 1.42 (0.017) | 1.45 (0.042) | 1.83 (5.4e‐4) | 1.56 (0.011) | |||
| GO negative regulation of Wnt signaling pathway* | 1.99 (8.3e‐4) | 1.63 (0.019) | |||||
| GO regulation of Wnt signaling pathway* | 1.41 (0.012) | 1.62 (2.3e‐3) | 1.77 (1.0e‐3) | 1.59 (3.3e‐3) | |||
| GO cell signaling by Wnt* | 1.52 (4.7e‐3) | 1.70 (1.0e‐3) | 1.48 (6.0e‐3) | ||||
| GO negative regulation of canonical Wnt signaling pathway | 1.90 (2.2e‐3) | ||||||
| GO beta catenin TCF complex assembly | 1.87 (0.019) | ||||||
| REACTOME negative regulation of TCF dependent signaling by Wnt ligand antagonists | 1.87 (0.015) | ||||||
| REACTOME signaling by Wnt in cancer | 2.13 (6.3e‐4) | ||||||
| REACTOME Wnt ligand biogenesis and trafficking | 1.79 (0.047) | ||||||
| REACTOME formation of the beta catenin TCF transactivating complex | 2.00 (2.0e‐3) | ||||||
| REACTOME TCF dependent signaling in response to Wnt | 1.64 (0.013) | ||||||
| REACTOME signaling by Wnt | 1.48 (0.036) | ||||||
*
Terms belonging to the top 20 list of Fig. 5A.