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. 2022 Mar 17;36(7-9):480–504. doi: 10.1089/ars.2021.0023

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© Sharmila Fagoonee et al., 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 4. — Small RNA-seq analysis of circulating EVs in BDL mice. (A) PCA analysis. (B) Venn diagram showing the distribution of murine miRNAs enriched in plasma-derived EVs after BDL; miRNAs upregulated at 8d BDL only or 15d BDL only or progressively from 8d to 15d are represented. (C) Heat map showing 66 conserved miRNAs enriched in EVs after BDL with respect to sham controls. (D) Criteria used to select miRNAs for validation are shown. PCA, principal component analysis. Color images are available online.